One of the main reasons for the loss in the drug development pipeline is drug toxicity. However, due to the inability of animal models to predict various human adverse drug reactions, drug toxicity is difficult to predict in the early stage of drug discovery.

Creative Bioarray is committed to establishing in vitro models simulating organ function in vivo through cell patterning technology to accurately evaluate the hepatotoxicity, nephrotoxicity and cardiotoxicity of drugs, and provide detailed potential mechanism information to help you make decisions earlier in the process of drug development.

Cell Patterning for Evaluating Hepatotoxicity

The poor predictability of human hepatotoxicity still leads to the high attrition rate of candidate drugs in the pharmaceutical industry in the non-clinical, clinical and post marketing authorization stages. It is mainly because animal models can't predict various adverse drug reactions in humans, resulting in no hepatotoxicity detected in the non-clinical stage of drug development. In order to increase the prediction of human hepatotoxicity, various methods have been developed to enhance the physiological relevance of the liver in vitro.

Our cell patterning technology can better summarize hepatocyte tissue and cell-matrix contact, including additional cell types, combine fluid flow and produce gradients of oxygen and nutrients, so as to improve differentiated cell phenotype and function. The in vitro liver model established by our cell patterning technology can maintain the morphology, viability, functional stability and metabolic capacity of hepatocytes, preserve liver specific gene expression in long-term culture, and allow acute toxicity research and long-term evaluation.

Cell patterning for Evaluating Nephrotoxicity

In preclinical trials, only 7% of new therapeutic drugs failed due to their nephrotoxicity, but in about 20% of cases in hospitals, the nephrotoxicity of drug compounds is also the main cause of acute renal injury. However, the existing in vitro models for studying nephrotoxicity do not fully summarize the biological function of kidneys.

Our cell patterning technology can replicate complex renal structure, simulate renal function in a more physiologically relevant way, summarize the filtration, absorption and excretion of drugs by the kidney, and realize natural kidney like behavior. The in vitro kidney model established by our cell patterning technology can maintain the long-term stability of the specific function of the kidney. Even if repeated administration, it can maintain the sensitivity of drug-induced renal injury prediction without losing specificity. Therefore, the model can greatly improve the ability to effectively and efficiently test the nephrotoxicity of new compounds in the preclinical stage.

Cell patterning for Evaluating Cardiotoxicity

Drug induced cardiotoxicity is an important reason to hinder the development of compounds in preclinical and clinical practice. It represents one of the most serious side effects associated with new drug development and is one of the major toxic effects caused by several known drugs. Therefore, there is an urgent need for in vitro systems that can better predict drug-induced cardiotoxicity.

Through cell patterning technology based on micro processing in vitro, we can maintain the physiological and pathophysiological characteristics of cardiomyocytes, reproduce the electrical activities of cardiomyocytes, maintain the physiological characteristics of cardiomyocytes. The in vitro heart model established by our cell patterning technology shows more physiological relevance than the traditional model, and can achieve higher and stable function in a few weeks to promote the maturation of cardiomyocytes to mature heart tissue. This new model is sensitive to cytotoxicity that can damage cardiomyocytes and can faithfully predict human cardiotoxicity.

Get in Touch

Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.