Creative Bioarray provides you with an in vitro heart model based on the Cell Patterning. This service can provide you with an in vitro heart model with higher physiological relevance, so as to improve the predictive value of preclinical research, and ultimately help you make decisions earlier in the development of cardiac drugs for the study of the basic mechanism of the heart Cardiac drug screening and regenerative medicine provide a powerful tool.

Why Cell Patterning for In Vitro Heart Models?

At present, the response of traditional 2D cultured heart cells to drugs, toxins or signal regulators is increasingly proved to be lack of credibility. For more than a century, animal models, transplanted hearts and later freshly isolated primary cells have been used to evaluate various parameters of cardiac cell physiology and electrophysiology, which greatly increases our understanding of the basic mechanism of the heart. However, animal models are relatively expensive and have ethical problems. In addition, there are differences between human and animal hearts, which will become more obvious and limited under pathological conditions. Due to the above limitations of the classical model, there is an urgent need to develop an in vitro heart culture system that can simulate the in vivo microenvironment to restore the in vivo conditions of a certain multicellular micro tissue. In short, the ultimate goal of developing a new in vitro heart model is to provide a bionic culture environment and provide a powerful tool for the study of the basic mechanism of the heart, cardiac drug screening and regenerative medicine.

Fig1. In vitro and in vivo models for studying the biology of a virus. (Pena, Lindomar José, et al.,2018)

Applications of Cell Patterning for In Vitro Heart Models

Creative Bioarray's in vitro heart models can summarize some physiological functions of the heart and be used in drug research to study the efficacy, safety and mode of action of therapeutic agents. In addition, our myocardial tissue engineering is to apply the principles and methods of engineering and life sciences to the basic understanding of the structure-function relationship between normal and pathological heart tissues and to develop biological substitutes to restore, maintain or improve tissue function. Our increasingly automated and miniaturized detection format provides higher content and more stability than traditional 2D culture, and promotes the maturation of cardiomyocytes to mature heart tissue. At present, our in vitro heart models have great application potential in the following aspects:

• Heart disease model
• Cardiac drug discovery
• Regenerative medicine and tissue engineering
• Cardiac toxicology

What Can We Do?

At present, people have gradually used the in vitro technology of human cells to replace animal research, and has had a significant impact. Creative Bioarray's in vitro heart models can continue to provide more evidence for the excellent prediction of clinical results of new drugs. Our existing in vitro heart models show more physiological correlation compared with animals or human tissues, and can continue to provide more evidence for the excellent prediction of clinical results of new drug. We build in vitro heart models for you through cell patterning methods such as co-culture, bioprinting and microfluidics. Our models can imitate thicker tissue in some heart disease models, and can customize the exclusive shape according to your application (screening, maturation, regeneration, medicine), which can partially replace the common animal experiments in this research field. The in vitro heart models we can provide mainly include the following categories:

• Microfluidic cardiac cell culture model
• Microfluidic heart model
• Co-cultures of cardiomyocytes and fibroblasts
• Heart-on-a-chip model
• Heart disease model (cardiac fibrosis, atrial fibrillation)

Why Choose Us?

• The models can be quickly formed and ready for drug treatment and analysis
• The models have higher physiological correlation.
• Scientific and reasonable scheme design
• Rich experience in cell patterning projects
• High quality and fast service

Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.

Reference:

1. Pena, Lindomar José.; et al. "In vitro and in vivo models for studying Zika virus biology." The Journal of general virology. 2018;99(12),1529-1550.