Relationship Between Cell Patterning and Drug Discovery

Generally, in order to evaluate the efficacy of drugs, 2D in vitro cell culture models are used to monitor the effects of drugs on target cells and normal cells in vivo. However, the data obtained are often too limited and can't accurately predict the side effects of different drug doses and interactions on the whole human body or target organ system. In addition, in view of the great differences between animal and human physiology, animal models are gradually considered not to represent human systems. Therefore, there is an urgent need to develop new methods that can more faithfully represent human physiology and pathology to promote drug discovery.

Creative Bioarray has leading 3D cell patterned culture technology, including spheres, organoids, organ-on-a-chip and 3D bioprinting. Our cell patterning technology allows to simulate and shape the microenvironment in cells in vitro, control the interaction between cells and various components of their microenvironment, and establish physiologically related in vitro models, including heart, kidney, liver and blood vessels. Our cell patterning technology can be used for disease modeling, target identification and verification, screening and drug efficacy and safety evaluation, so as to improve the accuracy of drug compounds and reduce development costs, open the door for preclinical screening of personalized candidate drug groups, improve results and reduce side effects of drug treatment.

What Problems Can Our Cell Patterning Technology Help You Solve in Drug Discovery?

Cell Patterning for Disease Modeling

In recent years, as more and more efforts turn to unmet treatment needs, disease modeling has become more and more important for the success of drug discovery programs. Our cell patterning for disease modeling can bridge the gap between 2D culture and in vivo culture, and can be used to understand the mechanisms of cancer, cardiovascular disease and central nervous system disease. Through cell patterning technology, we can combine the traditional cell culture matrix with the physiological correlation in vivo, reproduce various biochemical and biophysical conditions, and simulate the natural microenvironment of tissues / organs, so as to improve the correlation and repeatability of the data generated by drug screening in vitro, and open up a new way to understand the disease mechanism and drug screening.

Cell Patterning for Evaluation of Drug Toxicity

One of the main reasons for the loss in the drug development pipeline is drug toxicity. However, because the animal model can't accurately predict various human drug adverse reactions, drug toxicity is difficult to predict in the early stage of drug discovery. Our cell patterning technology can replicate complex organ structures, maintain cell morphology, cell viability and functional stability, and simulate organ functions in a more physiologically relevant way. The in vitro model established by cell patterning technology can accurately evaluate the hepatotoxicity, nephrotoxicity and cardiotoxicity of drugs, even allow acute toxicity research and long-term evaluation, and provide detailed potential mechanism information. We can help you effectively and efficiently test the toxicity of new compounds in the preclinical stage and make decisions earlier in the drug development process.

Cell Patterning for Drug Screening

New drug development is often hampered by cost and time span. Our cell patterning technology is an easy to obtain and cost-effective drug screening method. Compared with the traditional drug screening methods based on Petri dish and animal research, our cell patterning has many advantages, such as small volume, easy to use, high sensitivity, large flux and so on. Through cell patterning technology, we can provide an ideal controlled environment for cell culture and drug testing, and can carry out microvascular perfusion and diffusion between simulated microvessels and 3D cell culture, so as to make the microenvironment closer to the situation encountered by cells in real tissues or organs. In addition, the microchannel structure in our microfluidic cell patterning can greatly reduce the amount of reagent required for compounds. This reduction in reagent demand is accompanied by the simplicity and increase of parallel testing, so as to realize high-throughput screening of more candidate compounds.

Get in Touch

Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.