Based on Cell Patterning, Creative Bioarray uses cell patterning technology to provide you with kidney models that can accurately summarize the physiological status of human kidney, and provide a comprehensive in vitro nephrotoxicity assay to accurately evaluate the nephrotoxicity of drugs, and provide detailed potential mechanism information to help you make decisions earlier in the process of drug development.

Why Cell Patterning for Drugs-induced Nephrotoxicity Detection?

The kidney is very sensitive to the toxic effects of compounds, industrial, household and environmental chemicals, food additives and natural substances. The nephrotoxicity of drug compounds is also the main cause of acute renal injury. Due to the limitations of predictability of animal models, about 90% of candidate drugs fail in human trials. In addition, the existing in vitro models for studying nephrotoxicity do not fully summarize the biological function of kidney. In preclinical trials, only 7% of new therapeutic drugs failed due to their nephrotoxicity, but in 17% - 26% of cases in hospitals, the nephrotoxicity of drug compounds is the cause of acute renal injury. Relying on cell patterning technology, we can replicate the complex renal structure and establish a functional renal model, which can improve the ability to effectively and efficiently test the nephrotoxicity of new compounds in the preclinical stage.

Advantages

Through cell patterning technology, we can replicate the complex renal structure, simulate the renal function in a more physiologically relevant way, simulate the physiological environment, summarize the filtration, absorption and excretion of drugs by the kidney, realize the natural kidney like behavior, and establish a functional in vitro kidney model, which can't be realized in the traditional model. The model is a powerful tool to clarify the potential mechanism of cell injury and predict the response to poisons in vivo. It is of great significance for you in drug screening and nephrotoxicity discovery.

What Can We Do?

We have established a variety of in vitro kidney models by cell patterning technology. These models allow accurate control of the cell microenvironment to maintain the specific function of the kidney and maintain the long-term stability of renal cell function. Even if repeated administration, they can maintain the sensitivity of drug-induced renal injury prediction without losing specificity.

In addition, we provide a comprehensive in vitro nephrotoxicity assay, including cytotoxicity test, mitochondrial stress assessment and biomarker (KIM-1 and NGAL) detection. We focus on providing you with reliable cell culture models and thoughtful detection services to accurately evaluate the nephrotoxicity of drugs and provide detailed information on the potential mechanism.

Why Choose Us?

• Long term renal toxicity study
• Maintain kidney-specific function
• Compatible with high content imaging readings
• Scientific and reasonable scheme design
• High quality and fast service

Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.