Creative Bioarray provides you with microfluidic cell patterning based on Cell Patterning. This service can provide you with more suitable microfluidic chips, so as to realize high-throughput drug screening and become a favorable tool for you to study cell biology.

Why Patterned Cell Culture Inside Microfluidic Devices?

Drug development involves several main processes, such as drug discovery, preclinical trials and clinical trials. Drug analysis runs through the whole process of drug development. However, this complex process still faces the challenges of major problems such as time consumption, low throughput and high cost. Therefore, there is an urgent need for more powerful and faster methods to screen and verify potential drug candidates in order to provide effective improvement and cost reduction for the drug discovery process.

Microfluidic cell patterning is a miniaturization technology that can provide both analytical efficiency and high flux capability without loss of accuracy and automation. In the process of drug application, microfluidic cell patterning is not only a powerful tool for rapid screening and analysis of drug discovery, but also reduces the cost and reagent consumption through its miniaturized device. Compared with traditional cell detection systems, the emerging microfluidic chip technology has great advantages in high-throughput drug screening, and has been recognized as a favorable tool for cell biology research.

Fig.1 Application of microfluidic chip in drug screening. (Cui P, et al.,2019)

Applications of Patterned Cell Culture Inside Microfluidic Devices 

Compared with the traditional cell analysis system, the emerging microfluidic chip technology has great advantages in high-throughput drug screening, and has been recognized as a favorable tool for cell biology research. In addition to the common advantages of microfluidics, including high-throughput characteristics, low reagent consumption and integration potential, the most influential advantage of microfluidics for cell-based drug detection and analysis is the ability to drive fluids and manipulate biological particles (such as DNA, RNA, protein and cells) on a microscale. At present, microfluidic technology has been applied to a variety of research fields:

• Clinical analysis and diagnosis
• Life science research
• Gene expression analysis
• Proteomic analysis
• High throughput screening
• Organ chip
• Cancer research

These applications provide new insights into biological processes and can efficiently and quickly generate new drug analysis. Our microfluidic technology is being used to develop a cost-effective in vitro model of lead compounds that can more reliably predict the efficacy, toxicity and pharmacokinetics of drug compounds in humans, as well as for new screening tests.

What Can We Do?

Our microfluidic chip can be made into extremely complex microchannels and microdomains, and can be combined with substrates and additional chips of different materials to realize different functions through various control valves, such as liquid flow, cell culture and concentration gradient. The different forms of microfluidic chips we provide can be used for drug screening, improve screening efficiency and reduce cost. At the same time, the research of microfluidic flow takes place at the micron or nano level. Based on the above technologies, we can provide you with the following services:

• Cell Culture Inside Microfluidic Devices
• Organ chip (liver, kidney, lung, intestine and heart)
• Gene analysis based on microfluidic chip
• Protein analysis based on microfluidic chip
• Cancer cytological analysis using microfluidic systems (e.g., cell sorting, single cell analysis)
• High throughput screening of drugs based on microfluidic chip

Why Choose Us?

• Complete the customized design structure to realize different functions
• combined with different devices and test equipment to expand its application range
• Scientific and reasonable scheme design
• Rich experience in cell patterning projects
• High quality and fast service

Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.

Reference:

1. Cui P.; et al. Application of microfluidic chip technology in pharmaceutical analysis: A review. J Pharm Anal. 2019;9(4):238-247.