A major challenge facing tissue engineering is to manufacture vascular structures containing vascularized tissue structures to reproduce viable, complex and functional organs or tissues, as well as independent vascular structures that may provide clinical applications in the future. As a promising technology, cell patterning based on bioprinting has many advantages that other traditional biological manufacturing methods do not have.

Creative Bioarray is committed to opening up a new way for traditional tissue engineering to prepare blood vessels and vascularized tissues through cell patterning technology. We aim to provide practical solutions to solve the problem of vascularization and promote the clinical transformation of tissue-engineered blood vessels.

Cell Patterning for Vascularized tissue Structure Establishment

The immediate vascularization of the implanted tissue structure is very important, otherwise the cell viability and biological function of a large number of engineering structures may be rapidly damaged, especially when the structure is more than 150-200 mm away from the functional microvascular system. In the past few decades, a lot of efforts have focused on the engineering of vascularized tissue and organ structures, especially the vascular system and microvascular system in large structures.

Through the patterning technology based on 3D bioprinting, we can realize the pre vascularization of tissue structure and the reconstruction of the complex structure of the vascular system in vivo. This process involves the use of cell load or cell compatible bio ink in a continuous, layer by layer manner to make lump matrix into a blood vessel bed, and also requires rapid gel / crosslinking to obtain sufficient stability of the structure.

In addition, we can replicate the structure of vascularized tissue in vitro through cell patterning, including a series of branch blood vessels, from small diameter blood vessels of millimeter size to micron size capillary networks supporting tissue-specific functions. We can provide a long-term and stable cell-based solution for supplying oxygen and nutrition to tissues, which is essential for the sustainable growth and survival of tissues.

Cell Patterning for Independent Vascular Structure Establishment

Independent tubular structures are arranged to be used as artificial blood vessels in 3D tissue structures or as vascular medical grafts to replace diseased blood vessels. However, manufacturing self-supporting blood vessels that can replicate the natural vascular system anatomically and functionally remains a serious challenge. Ideally, tissue-engineered blood vessels should have the same three-layer structure as primary blood vessels, including outer mold, middle membrane and inner membrane, and have the functions of contraction and relaxation, nutrients and oxygen permeation.

Our cell patterning technology based on biological 3D printing has many advantages over other biological manufacturing methods. Relying on this technology, we can effectively build a three-dimensional vascular network to promote the transportation of oxygen, nutrients and waste. We have opened up a new way for traditional tissue engineering to prepare blood vessels and vascularized tissues.

We can provide practical solutions to solve the problem of vascularization and promote the clinical transformation of tissue-engineered blood vessels. We are not only limited to biological printing multi-scale complex structure vascular network, but also can ensure the fidelity and stability of its structure. In addition, by accurately locating different kinds of cells, proteins and even genetic materials, we can control the time and space division ratio of biological printing blood vessels on demand, so as to truly achieve intelligent, automated and personalized biological manufacturing.

Get in Touch

Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.