Based on Cell Patterning, Creative Bioarray can use cell patterning technology to help you establish functional in vitro neural tissues. The development of this model provides an important opportunity to simulate human nervous system diseases. In addition, this new in vitro model provides a powerful tool for you to study the potential pathogenesis of nervous system diseases, which can be used to clarify the molecular drivers of various neurological diseases or as a high-throughput drug screening platform.

Why Cell Patterning for Skin Tissues?

Skin, as the largest organ in direct contact with the outside world, is also the most vulnerable organ. Although the skin has higher regeneration ability than most tissues, large-area and deep injury can lead to the failure of complete repair of the original cellular environment, resulting in the failure of hair follicle and sweat gland regeneration, which seriously affects the prognosis and quality of life of patients.

The most common treatment for skin defects is autologous skin transplantation. However, the shortage of donor sites, secondary injury and infection risk limit the application of autologous skin transplantation. 3D bioprinting is one of the cell patterning technologies and one of the main tissue engineering technologies. Compared with traditional methods, it has the advantages of multi-cell spatial directional manipulation and controllable deposition of different cell densities. Its precision and high resolution allow us to print functional skin and appendages. It is a new method for the treatment of skin defects.

Fig1. Steps in the fabrication of bioprinted skin. (Augustine R, et al.,2018)

Applications of Cell Patterning for Skin Tissues

At present, there are more and more cases of skin defects caused by trauma, burns, ulcers and surgical trauma. The introduction of 3D bioprinted skin makes it possible to customize autologous skin for patients' wounds or directly carry out in-situ skin bioprinting to treat wounds. In addition to wound treatment, 3D bioprinted skin can also be used as an in vitro model for cosmetic and chemical testing. The European Union has issued a decree prohibiting the testing of cosmetic ingredients on animals. Using 3D bioprinted skin tissue for product testing and development can solve the ethical problems of animal experiments. In addition, 3D bioprinting can generate skin disease models for pathophysiological research, drug screening or in vitro treatment effect evaluation.

What Can We Do?

Our in vitro skin tissue model is manufactured by cell patterning technology of 3D bioprinting, which is mainly divided into three categories: extrusion, droplet and laser bioprinting. Our technology uses rapid prototyping technology to print cells, growth factors and other biomaterials layer by layer to produce skin tissues that maximize the complexity of active skin tissue and provide you with higher repeatability, accuracy and relevance.

Our 3D printing technology is a powerful tool for constructing bioengineering skin tissues. Compared with the traditional model, our 3D printing technology can quickly print the skin graft matching the wound according to the shape and depth of the wound. In addition, we have a variety of biological inks available, which can flexibly and accurately deposit different biological agents to construct skin tissue structure, and their morphology and physiology are similar to normal skin. In conclusion, we can accurately print skin and skin substitutes with high biocompatibility and low immunogenicity according to your needs, and provide you with reliable skin models for pathophysiological research, drug screening or in vitro treatment effect evaluation. We can provide you with the following skin tissues:

• Full thickness skin
• Vascularized skin
• Skin with skin pigmentation function
• Skin appendages including sweat glands and hair follicles

Why Choose Us?

• High biocompatibility and low immunogenicity of skin model
• Allow personalized customization
• Scientific and reasonable scheme design
• Rich experience in cell patterning projects
• High quality and fast service

Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.

Reference:

1. Augustine, R.; et al. Skin bioprinting: a novel approach for creating artificial skin from synthetic and natural building blocks. Prog Biomater.2018, 7(2):77–92