Based on Cell Patterning, Creative Bioarray provides you with cell patterning for conditioning cell apoptosis service to accurately control the cell shape and microenvironment, so as to facilitate you to study cell apoptosis under well controlled conditions. In addition, our cell patterned culture allows highly repeatable quantification of apoptotic cells (such as primary neurons), which has become a powerful tool for you to study apoptosis related diseases.

Why Cell Patterning for Controlling Cell Apoptosis?

The pattern and development of multicellular organisms need a precise control balance between cell proliferation, differentiation and death, and the regulation of apoptosis is an important aspect to achieve this balance. Studies have shown that cell shape may play an important role in controlling apoptosis and growth. Cell patterning is a technology to control the basal surface and cell geometry. It can accurately control cell morphology (including size, shape and interconnection), so as to control cell apoptosis. In a word, cell patterning can overcome the technical obstacles existing in the current biological research, and will become a powerful tool to promote the research of apoptosis related diseases.

Fig.1 Effect of patterned cell size on apoptosis and growth. (Melissa C, et al.,2020)

Applications of Cell Patterning for Controlling Cell Apoptosis

Apoptosis is an evolutionarily conserved cell death pathway, which is responsible for the programmed elimination of cells in the process of normal eukaryotic development and maintaining body homeostasis. It plays a central role in the maintenance of self-tolerance and homeostasis control of lymphocyte population in the immune system.

Cell patterning technology is helpful to analyze the molecular mechanism of dysregulated apoptosis, so as to reveal the ways of more effective therapeutic intervention. In addition, inhibition of apoptosis can produce enhanced living cell biomass. The application of this method to recombinant mammalian cells is expected to improve the cost-effectiveness of industrial scale protein expression.

What Can We Do?

There are three main types of cell patterning techniques for controlling apoptosis. Cells adhere to chemically patterned surfaces with cell adhesion ECM protein patterns, cell localization using physical cell constraints, and cell position control using optical and magnetic tools. Our comprehensive technology allows us to control the size and distribution of the adhesion area by providing contact guide wires, so as to accurately control the cell shape and microenvironment, so as to facilitate you to study apoptosis under well controlled conditions.

The loss of important cells in healthy tissues can lead to the development, progression and treatment results of many human diseases, including neurological and infectious diseases, as well as environmental and medical toxicity. Conversely, abnormal survival and accumulation of damaged or excess cells can lead to significant human pathology, such as cancer and autoimmune diseases.

Our cell patterned culture allows highly repeatable quantification of apoptotic cells (such as primary neurons), which has become a powerful tool for you to study apoptosis related diseases.

Why Choose Us?

• Precise control of cell position
• High repeatability of results
• Scientific and reasonable scheme design
• Rich experience in cell patterning projects
• High quality and fast service

Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.

Reference:

1. Melissa C.; et al. 3D Bioprinting of Neural Tissues. Advanced Healthcare Materials.2020,2001600.