Based on Cell Patterning, Creative Bioarray can use cell patterning technology to help you control cell shape, and provide services such as building neural networks, predicting cell line metastasis, identifying cancer phenotype and predicting stem cell phenotype, so as to assist your biological research process, speed up drug screening and improve the efficiency of preclinical drug discovery.

Why Cell Patterning for Cell Morphology?

Cell morphology is an emergent characteristic of cell phenotype, cell physiology and signal state. The change of cell shape will lead to the characteristic change of cell phenotype. Therefore, controlling cell shape may become another mechanism to regulate cell function to promote human health. Cell patterning technology can manipulate the physical and chemical guidance clues of cultured cells, such as cell size barriers or grooves used to guide the growth of axons and dendrites, and patterned protein islands used to guide the location of cell bodies. Controlling cell adhesion through cell patterning technology enables us to impose boundary conditions in cell culture, so as to restore the ability to control its shape and structure.

Fig.1 Cell shape affects cell state. (Prasad A, et al.,2019)

Applications of Cell Patterning for Cell Morphology

Cell patterning technology can directly control the cell shape by providing contact guide wires to control the size and distribution of adhesion areas. In the past few years, cell patterning has provided important technical support for the study of the mechanism of cell shape affecting cell phenotype, leading to the gradual deepening of the study of cell morphology. These studies provide substantial evidence that cell morphology is sensitive to specific cell changes and repeatable. At present, many applications related to the form and function of cells have been found, such as

• Morphological study
• Diagnostic cytology
• Genetics
• Tissue engineering
• High throughput drug screening

What Can We Do?

Our patterning method for controlling cell shape is mainly microcontact printing, which is a mature cell patterning method, which can control cell shape and microenvironment, so as to allow the study of cells under well controlled conditions. Specifically, through our cell patterning technology, you can not only accurately control your cell geometry, but also strictly control the position and size of adhesion points.

Studies have shown that cell morphology, as an information readout, is closely related to the basic physiological characteristics of cells, such as cell cycle progression, cell adhesion, cell electrophysiological characteristics, cell differentiation, drug reactivity, aging, gene expression pattern and invasive potential. Our powerful service platform allows us not only to control your cell morphology, but also to assist you in completing relevant research. In addition, because the cell morphology is relatively sensitive to physiology, we can also use the morphological changes of apoptosis to quickly and sensitively screen small molecules for your cytotoxicity research.We can provide you with the following services according to your research needs

• Customized patterned cell models according to your needs (such as smooth muscle cells in blood vessels with contractile phenotype, neurons with controllable excitability, stem cells with controllable differentiation direction)
• Accurately manipulate the morphology of neurons and establish a patterned neural network
• Predicting the metastatic ability of cell lines
• Identify cancer phenotypes
• Predicting the phenotype of stem cells
• High throughput drug screening

Why Choose Us?

• Precise control of cell geometry
• Comprehensive services in various research fields
• Scientific and reasonable scheme design
• Rich experience in cell patterning projects
• High quality and fast service

Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.

Reference:

1. Prasad A.; et al. Cell Form and Function: Interpreting and Controlling the Shape of Adherent Cells. Trends in Biotechnology. 2019, 7(4):347-357.