Based on the Cell Patterning, Creative Bioarray can use cell patterning technology to help you establish accurate spatial patterns and create different levels of cartilage tissues. We can customize the personalized cartilage structure according to your needs to promote the research and development of your cartilage regeneration, and help you open up challenging joint defects and potential new therapies for osteoarthritis.

Why Cell Patterning for Cartilage Tissues?

Articular cartilage is a transparent tissue covering the bone end, which can realize free movement, load-bearing and distribution. However, the cartilage injury can't heal itself, resulting in the gradual damage of joint structure and function. Its low self-healing ability leads to the formation of fibrous scar tissue with poor mechanical and biochemical properties compared with natural tissue. Therefore, joint tissue tends to deteriorate with the subsequent development of chronic disabling diseases, such as osteoarthritis.

In the past few decades, tissue engineering aimed at combining scaffolds and cells has become a promising strategy for cartilage regeneration. As a category of cell patterning, 3D bioprinting is a novel and innovative method, which can overcome the inherent shortcomings of traditional methods (limited source of autologous cartilage transplantation, ethical problems of immune rejection, etc.), and has great potential in cartilage tissue engineering. Using this technology, we can copy the structure of articular cartilage and meniscus, and even create personalized macro and micro cartilage structures.

Fig.1 Comparison between traditional tissue engineering and 3D bioprinting methods. (Roseti L, et al.,2018)

Applications of Cell Patterning for Cartilage Tissues

Osteoarthritis is a degenerative disease of cartilage, which can lead to erosion of joint surface and loss of activity. Its universality emphasizes the importance of developing functional articular cartilage substitutes. 3D bioprinting technology brings hope to regenerative medicine because it can print tissues and organs on demand. 3D bioprinting allows the distribution of different cells and supporting biomaterials in a complex way with high spatial resolution to simulate the microstructure of different tissues. The purpose is to generate new living tissues to replace diseased/damaged tissues and restore tissue/organ functions.

The purpose of constructing cartilage tissues using 3D bioprinting technology is to improve the tissue engineering method of repairing cartilage in the animal model of disease damage, so as to better understand the clinically feasible design and provide a model system for the study of normal and pathological cartilage tissues.

What Can We Do?

Our in vitro cartilage models are manufactured by cell patterning technology of 3D bioprinting, which is mainly divided into three categories: extrusion, droplet and laser bioprinting. Our technology can generate accurate spatial patterns and create different levels of cartilage tissues by controlling different biomaterial properties and cell types in each print layer. Our technology can realize the collaborative printing of living cells, biomaterials and growth factors, create personalized macro and micro structures, and construct bioactive cartilage tissues.

Our 3D printing technology is a powerful tool for constructing bioengineering cartilage constructs. Compared with traditional models, 3D printing technology creates organized living structures by "layer by layer" deposition of small units of biomaterials and cells, and shows the important advantages of simulating natural cartilage over traditional methods by fine controlling cell distribution and adjusting mechanical and chemical properties.

Our goal is to customize the personalized cartilage structure according to your needs, so as to promote the research and development of your cartilage regeneration, and help you open up challenging new therapies for joint defects and potential osteoarthritis.

Why Choose Us?

• Precise space control and personalized design
• Create personalized macro and micro structures
• Scientific and reasonable scheme design
• Rich experience in cell patterning projects
• High quality and fast service

Creative Bioarray provides customers with cell patterning customization and related detection services based on Cell Patterning, you can contact our employees directly to ask questions if you are interested in our services, please contact us for more details.

Reference:

1. Roseti, L.; et al. Three-dimensional bioprinting of cartilage by the use of stem cells: a strategy to improve regeneration. Materials.2018, 11(9):1749.